Condensin-Mediated Chromosome Folding and Internal Telomeres Drive Dicentric Severing by Cytokinesis
نویسندگان
چکیده
منابع مشابه
Condensin-mediated chromosome organization and gene regulation
In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the sexes. Dosage compensation initiates as cells transition from pluripotency to differentiation. In Caenorhabditis elegans, dosage compensation i...
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Although condensin protein complexes have long been known for their central role during the formation of mitotic chromosomes, new evidence suggests they also act as global regulators of genome topology during all phases of the cell cycle. By controlling intra-chromosomal and inter-chromosomal DNA interactions, condensins function in various contexts of chromosome biology, from the regulation of...
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Functional links connecting gene transcription and condensin-mediated chromosome condensation have been established in species ranging from prokaryotes to vertebrates. However, the exact nature of these links remains misunderstood. Here we show in fission yeast that the 3' end RNA processing factor Swd2.2, a component of the Cleavage and Polyadenylation Factor (CPF), is a negative regulator of ...
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To segregate chromosomes properly, the cell must prevent merotely, an error that occurs when a single kinetochore is attached to microtubules emanating from both spindle poles. Recent evidence suggests that cooperation between Pcs1/Mde4 and condensin complexes plays an important role in preventing merotely.
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In human diploid cells, 23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle. Upon exit from mitosis, they decondense and are packed together into the nucleus, in which individual chromosomes are no longer discernible. Nonetheless, evidence accumulated during past decades suggests that the decondensed chromosomes are not...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2019
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2019.05.021